Prevention of strokes, heart attacks and other dangerous cardiovascular conditions must include high blood pressure managing therapy. Zestoretic, which combines two active agents and helps to treat hypertension, is a great option. In addition, this medicine helps reduce the amount of odd salts in the body, thus, reducing the risk of kidney problems.
Mechanism of Action
The action of Zestoretic is based on Lisinopril and Hydrochlorothiazide. The first component, Lisinopril, functions by inhibiting angiotensin-converting enzyme. It helps to decrease vasopressor activity and aldosterone production. In simple words, Lisinopril relaxes blood vessels improving the blood flow. Hydrochlorothiazide is responsible for plasma renin activity increase. Also, it helps to normalize serum potassium levels which might be increased due to Lisinopril action. Belonging to the class of diuretics, hydrochlorothiazide helps to get rid of extensive amount of odd salts and water in body.
Zestoretic is a prescription drug, which means the dosage each patient needs might be quite specific, so it is important to follow your doctor’s recommendations when taking the medicine to avoid unwanted side effects and make the medication the most beneficial. The maximum possible dosage is 50 mg of Hydrochlorothiazide and 80 mg of Lisinopril, which means two pills of Zestoretic 20-25 a day with possible addition of ACE inhibitor.
As a rule, the medicine is taken once a day in the morning. As Zestoretic has a diuretic effect, it is not recommended to take it just before going to bed not to interrupt sleep. In case some drugs to lower cholesterol are taken, it is advised to make a gap of 4-6 hours before and after Zestoretic administration.
Due to the fact that different proportion of Lisinopril and Hydrochlorothiazide is appropriate in each case depending on a person’s state and sensitivity to the medicine, several types of Zestoretic are available on the market: 10-12.5, 20-12.5 and 20-25, where the first number is amount of Lisinopril and the second one stands for amount of Hydrochlorothiazide.
Zestoretic should not be used in case of:
Allergy to the active agents of the medicine;
Past experience of severe allergic reaction to any ACE inhibitor;
Being unable to urinate;
Dosage of Zestoretic and whether it is worth taking it at all might be determined by the conditions mentioned below. So, tell your doctor about any of them to make Zestoretic therapy safe:
Liver and kidney diseases.
The most common side effects are the following:
Possible dangerous side effects which need urgent medical help include:
Vision problems and eyes hurting;
Abnormal urination (extremely little or excessive);