Being a broad-spectrum antibiotic, this medicine is used to treat diseases caused by bacteria. The active agent of Terramycin is oxytetracyclineб which acts by binding to the 30S ribosomal subunit, thus, inhibiting the growth of bacteria. In other words, it affects bacteria, so that they lose ability to produce proteins necessary for their existence. Due to the fact the active component is lipophilic, there is no difficulty for it to pass through the membranes to get into target cells.
Terramycin is available in various forms, including intramuscular solutions, ointment and tablets.
As far as the medicine is a broad-spectrum antibiotic, it is used to treat various infections caused by:
It is exclusively effective in treating tularemia, Lyme disease, cholera, nonspecific urethritis, brucellosis and typhus. The ointment is mainly used in case of ocular infections.
Terramycin dose highly depends on the form indicated and type of the disease. As a rule, adults receive the amount of 1-2 g of oxytetracycline which is taken withing about 4 doses. Children who are older than 8 receive the daily dosage of 25-50 mg per kilo. Therapy with Terramycin might last from 1 to 10 days, depending on the type of infection. If you take tablets or capsules instead of injections, it is recommended to take them with a sufficient amount of water one hour before meals or two hours after eating something. It is necessary to avoid taking the medicine together with dairy products, as they affect the absorption of oxytetracycline.
In case Terramycin ointment is prescribed, half an inch should be applied carefully onto the lower lid. The procedure should be carried out from 2 to 4 times a day.
Warnings and Contraindications
It is evident that Terramycin is contraindicated for patients with hypersensitivity or allergy to any tetracyclines. Also it is not recommended to prescribe the drug to pregnant or breastfeeding women, infantry patients and children under 8 unless there is no other drug effective or allowed. If a patient suffers from renal impairment, dosage or frequency of administration must be decreased. The same is about patients treated with anticoagulants, whose dosage must be adjusted not to interfere with the action of Terramycin.
Penicillin should not be taken during tetracycline therapy. If an infection caused by insusceptible organisms appears, the current therapy must be stopped and another one instituted. Long Terramycin treatment should be accompanied by regular laboratory tests to check the state of the body systems.
The most frequent side effects which might be caused by this medicine are gastrointestinal:
Nausea and vomiting;
Also skin reactions such as photosensitive allergy, rash and dermatitis are often observed. In addition, there may be damage of the organs which contain calcium.