Prometrium (progesterone) is a drug belonging to the category of progestins. It is administered in a combination with ERT (estrogen replacement therapy) to treat and/or prevent endometrial hyperplasia (particularly in menopausal women). The condition causes the internal uterine lining to thicken and increases the likelihood of uterine cancer. Also, the drug is used to treat secondary amenorrhea.
Mechanism of Action
Progesterone is a synthetic medicine that is identical to natural progesterone, which is produced in ovaries. This hormone regulates and maintains the menstrual cycle. Particularly, it controls the growth of the uterine lining (endometrium), thus, mimicking the second post-ovulation half of the cycle, when estrogen levels decline and progesterone levels increase. In menopausal women, this process has to be stimulated artificially. They take Prometrium to stop the growth of the lining and reduce the likelihood of cancer.
Prometrium is a prescribed drug and should be used as directed by your doctor. Also, it must be administered under your doctor’s supervision. It is advisable to study the leaflet carefully. Please, follow your physician’s recommendations even if they run contrary to the leaflet.
How to Use Prometrium
Prometrium is available in 100 mg or 200 mg capsules. The dosage depends on the intensity of estrogen treatment, and a standard one is 200 mg a day. Doctors recommend administering Prometrium at bedtime for the last 14 days of ERT. Women, who receive high doses of estrogen, need to take 300 mg of Prometrium each day: 200 mg before going to bed, and 100 mg 2 hours after breakfast.
Do not store Prometrium in a bathroom. Store it in a dark and dry place away from sunlight;
Choose a place that is unreachable for children and/or pets;
Consult your pharmacist on how to dispose of expired capsules;
Do not throw them in a garbage can or flush them down the toilet or sink drain.
Precautions, Warnings and Contraindications
Prior to using Prometrium, tell your doctor about serious acute or chronic diseases you are dealing with or have dealt with earlier, if any. If you are sensitive to any of the drug’s components or other substances, even those not related to the drug, discuss them with your physician.
Avoid using Prometrium in the following cases:
You are pregnant, about to get pregnant, or are a nursing mother;
Have abnormal vaginal bleeding;
Have high blood sugar levels;
Suffer from cancer;
If your work requires concentration (driving, operating potentially traumatizing equipment, etc.);
Have mood swings, anxiety, depression.
Be very careful if you are already using ketoconazole, clarithromycin, isoniazid, tolvaptan, hydrocortisone, indinavir, lopinavir, etc.
The most likely to occur reactions are the following:
Changes in menstrual bleeding;
Swelling of face and limbs;