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Keflex

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Description

Keflex is a cephalosporin antibiotic of the first generation, which acts as a bactericidal medication, and the spectrum of its action is quite wide. Many microorganisms are sensitive to it: streptococci, salmonella, staphylococci, shigella, pneumococci, hemophilic rod, proteus, treponema, Escherichia coli, Klebsiella, etc. But some mycobacteria are resistant to its action, so the drug should be prescribed only after thorough analysis and by your doctor.

 

Pharmacological Effect

 

The drug is quickly absorbed from the digestive tract. The maximum concentration of the active ingredient in the blood will be reached in 60 minutes after the intake. Keflex permeates through all organs and tissues (pleural and pericardium membrane are penetrated as well). Excretion of the drug is provided by kidneys.

 

Indications for Use

 

Keflex is prescribed when there are pathologies of the following systems:

 

 Infections of the respiratory system caused by pathogens susceptible to Keflex (abscess of the lungs, bronchitis, pleurisy, pneumonia);

 Urinary system (cystitis, pyelonephritis, etc.);

 Reproductive system (vulvovaginitis, endometritis, epididymitis, etc.);

 Ear, nose and throat organs (otitis, pharyngitis, tonsillitis, etc.);

 Some skin diseases like pyoderma, furunculosis and others;

 Musculoskeletal system (osteomyelitis, arthritis).

 

Mode of Application

 

Keflex is prescribed for adults in a daily dose of 1-4 g; in some cases daily dosage of the medication can be increased up to 4-6 g. It is recommended to take the drug every 6 hours. The course of therapy is 1-2 weeks. The drug is prescribed for children at the dosage of 25-50 mg per kilogram of body weight. If the infection is caused by a gram-negative flora, the dose of the drug can be increased to 100 mg per day.

 

In some cases (not severe urinary tract infections, soft tissues, skin or pharyngitis of streptococcal etiology), the daily dosage can be separated between two intakes of the medication with an interval of 12 hours. Keflex should be used for at least 2-5 days more after the clinical improvement of a patient’s condition.

 

Side Effects

 

There might be adverse reactions in the gastrointestinal tract, such as dyspepsia or diarrhea, in very rare cases pseudomembranous colitis.

 

Other side effects include weakness, tremor, dizziness, allergic reactions (rarely up to anaphylactic shock) and blood reactions (eosinophilia, neutropenia, leukopenia).

 

Contraindications

 

The drug is contraindicated for patients with intolerance to cephalosporins and penicillin antibiotics. The use of Keflex during pregnancy is possible under the supervision of a doctor.

 

Drug Interactions

 

Keflex acts as a bactericidal antibiotic, so it is inappropriate to use it together with antibiotics that have a bacteriostatic effect (for example, tetracycline antibiotics, chloramphenicol). Be careful with the drug when it is combined with polymyxin, aminoglycosides, ethacrynic acid and furosemide. It is recommended to notify your healthcare provider about all the drugs that you use before Keflex is prescribed to you.

 

The possibility of prolonged prothrombin time should be considered when Keflex is used simultaneously with oral coagulants.

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