Aygestin (norethisterone) is a prescribed hormonal medication that is used to treat gynecological issues – menstrual disorders, endometriosis and amenorrhea. It belongs to the category of progestins. The basic component of the drug, norethisterone, is a synthetic equivalent of naturally secreted progesterone. Aygestin is used to control the growth of the uterus lining and even out the menstrual cycle. Do not use Aygestin without professional advice.
Mechanism of Action
Norethisterone is promptly absorbed into reproductive organs and glands regulating their functioning – the pituitary gland and hypothalamus. It binds to the progesterone receptor, suppresses the secretion of gonadotropin, controls ripening of follicles, ovulation and maintains the normal growth of mammary cells.
Use Aygestin in strict accordance with your doctor’s advice. Do as he/she says and do not rely on the leaflet alone. Do not increase or reduce your dose on your own. If you observe any side effects or have doubts about the drug’s effectiveness, discuss it with the doctor.
How to Use Aygestin
Aygestin is administered orally, and an average daily dose ranges between 2.5 mg and 10 mg. It depends on how severe your case is, reaction to the drug’s components and body size. The treatment course lasts from 5 to 10 days. Vaginal bleeding begins 3 to 6 days after discontinuation of the drug intake.
Stop or continue using Aygestin as advised by your doctor;
Do not change the dose without his/her recommendation;
Do not use expired Aygestin;
Ask your healthcare provider how to dispose of expired Aygestin;
Keep it out of the reach of pets and children.
Precautions, Warnings and Contraindications
Before administering Aygestin, make sure you are not allergic to any of its components. Be careful if you have a history of allergies to other substances. Do not use Aygestin if you are:
Hypersensitive to any of the drug’s components;
Pregnant, suspecting pregnancy or breastfeeding;
Suffering from blood clots in the legs, brain, lungs, or elsewhere in the body;
Prone to strokes, heart attacks, coronary artery disorder, congestive heart failure;
Susceptible to or suffering from kidney or liver problems;
Diagnosed with breast tumors;
Diagnosed with uterine, ovarian, cervical or vaginal cancer.
So far, Aygestin has not been thoroughly studied for interactions. However, some sources have reported influence on the secretion of hepatic enzymes, which wash progestins away from the body. In any case, if you are taking any other drugs right now, you should discuss their administration with your doctor and/or pharmacist.
Even though they rarely occur, some people may develop severe and potentially dangerous adverse reactions, such as:
Allergies: skin rash, blistering, wheezing breath, suffocation, swollen face and/or neck;
Diarrhea, nausea, vomiting, light-colored stools, dark urine (hepatic dysfunction);
Chest pain, coughing;
Dizziness, fainting, lethargy;
Abnormal vaginal bleeding;
Pain and numbness in the limbs;
Unstable mood, irritability.